A digital city is characterized by its increasing dependence on technological platforms for information and communication management that can enable the Internet of Things. These platforms make it possible to process a large amount of data and information to offer new services to the inhabitants of urban areas and new functionalities for the management of urban environment. In particular, the digital city can transform currently disparate design, construction, and operation phases of cyber-physical infrastructures into an open-source, cloud-based application featuring modulated digital twins of cyber-physical-social systems (roads, bridges, electrical grids, power plants, supply chains, etc.). Such a digital city initiative will enable grand-scale, fundamental and convergent research on the integrated design-build-operation process of infrastructure, examining its environmental implications, life-cycle assessments, and socio-economic impacts on community resilience in the case of catastrophic events.